BIOPEN® systems - Compound delivery for single cells
- Category: Microfluidic Chips
The BIOPEN® systems, developed by Fluicell, are unique and powerful microfluidic devices for maintaining localized drug delivery in single-cell experiments, enabling control of the chemical environment around single intact cells in tissue or cell cultures.
With the BioPen PRIME or the BioPen FLEX you can study and interrogate one or a small number of cells with a perfect control over the environment immediately surrounding the cell of interest.
Localized solution delivery platforms for single-cells
BioPen® PRIME and BioPen® FLEX systems are unique and powerful microfluidic platforms for maintaining localized delivery in single-cell experiments, enabling control of the chemical environment around single cells in tissue or cell culture.
Unique and critical data from single-cells
Collect unprecedented data quality at high resolution by controlling how much, when and where your reagents meet your cells.
- Interrogate single cells. Expose just one or a small number of cells to particular test solutions, e.g. drugs or antibodies, without diffusion outside the experimental region of interest. The test solution can easily be confined.
- Rapid delivery. Deliver four different solutions to just a single cell or part of a cell with sub-second exchange time.
- Low compound consumption. The four integrated solution reservoirs containing less than 35 μl, overcome typical dead volume problem of external tubing, reducing significantly the use of expensive reagents.
- Combination with other probing devices. The pipette tip has been optimized to fit into practically any micromanipulation environment allowing combination with other probes such as patch-clamp pipettes, optical fibers or electrodes.
- No glass or tip breakage. The pipette tips are made from a flexible biocompatible material so that unlike glass pipettes they won’t break upon contact with the hard surface.
- No contamination. The pipette tip has been developed from an hydrodynamically confined flow principle, enabling contamination-free confinement of one miscible liquid inside another.
The BioPen FLEX and BioPen PRIME systems are interchangeable component platforms; choose the holder and the pipette tip suitable for you.
BioPen® System contains:
1) Disposable pipette tip:
The pipette tip is used to deliver up to 4 different solutions. Utilizing hydrodynamic confinement, the delivered solution can be localized and rapidly switched without contaminating the rest of the cells or the cell dish solution. The pipette tip is made from PDMS. It includes 8 wells; 4 wells for containing solutions and 4 wells for collecting waste. Each well can contain up to 35 μl of solution.
Two types of pipette tips are available: PRIME and FLEX.
2) Pressure Controller:
Two levels of pneumatic pressure are supplied by the pressure controller and fast solution switching is achieved through the use of miniature solenoid valves.
3) Pipette holder:
The pipette holder is a pressure manifold to assure a closed system and to connect each solution reservoir of the pipette tip individually with the precision pressure controller. It has been designed to be compatible with any standard type of micromanipulator.
Two types of pipette holders are available: PRIME and FLEX.
The software enables facile configuration and use of the BioPen® system. The Windows-based BioPen® software allows independent control of each pressure line and solution delivery. It also includes a macro scripting module for automation of common tasks and setup/shutdown.
Deliver reagents locally to a single-cell or a group of cells, without contaminating the whole sample
BioPen® FLEX Tip Specifications
A) Schema of BioPen FLEX pipette
B) Schema of the tip of BioPen FLEX pipette
C) BioPen FLEX pipette exposure zone size
BioPen® PRIME Tip Specifications
A) Schema of BioPen PRIME pipette
B) Schema of the tip of BioPen PRIME pipette
C) BioPen PRIME pipette exposure zone size
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