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  • How to clean your microfluidic chip?

How to clean your microfluidic chip?

  • Tutorials
  • 23 Apr, 2021
  • Posted by: Christelle ANGELY

In most cases, it is possible to reuse a microfluidic chip several times. However, you should properly clean your chip after each use to avoid any loss of properties (e.g. coating), cross-contamination or clogging. For chips with complex structures (e.g. herringbone mixer), particles can easily get trapped and clog the chip.

In the following table, we have summarized the best cleaning protocols based on your application. These protocols apply to PDMS, glass, and most thermoplastics. Depending on the material, ethanol may be replaced by isopropanol for a better chemical compatibility.

Biofouling
Oil residues
Coating
Cleaning protocol
no
no
no
Distilled water / Ethanol 70% / Distilled water
yes
no
no
Distilled water / Ethanol 70% / Distilled water/ UV 30 min
no
yes
no
Distilled water / Ethanol 70% / Distilled water / SDS 10% / Distilled water
no
no
yes
Distilled water / Tween 20 / Distilled water
yes
yes
yes
Do not reuse 
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