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NETRI - DuaLink MEA Organ-on-a-Chip Platform
The DuaLink NeoBento™ features 8 chips per plate. The DuaLink architecture has been specially designed to create fluidic isolation and co-culture of up to 2 cell types. The plate features a MicroElectrod Array (MEA) layer to record the activity of the neurons. Both channels are connected by microchannels to allow 2 independant cell cultures. Neurons are used as bio-sensors, cell bodies growing in one channel and extensions in microchannels to reach and innervate any organs cultivated in the opposite channel. Recording and processing of electrophysiological data is made possible via MEA technology and NETRI's UpLink utility software.
The NeuroFluidics MEA Line by NETRI is fabricated in PDMS for high transparency and biocompatibility and is compatible with MEA-recording (Axion Maestro EDGE). This technology is ideal for developing high-throughput organ-on-a-chip models to accelerate drug development and disease modeling.
- Product SKU:
- NT-NF-DL-MEA-3
Support by a team of engineers & PhDs
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1,950.00€
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General
NETRI’s NeuroFluidics MEA Devices are MEA-capable compartmentalized organ-on-chip. They are innovative organ-on-a-chip platforms for organ modeling and drug discovery. They offer high-throughput data collection, including electrophysiology, with up to 16 data points on the same plate With their pump-free design and standard ANSI 96-well plate format, they can be seamlessly integrated with standard lab equipment and are compatible with a wide range of readouts for in-depth data analysis. NETRI’s platforms aim to model a wide range of organs and use neurons as bio-sensors to innervate those organs.
The DuaLink design of the NeuroFluidics Devices allows the culture of up to 2 cell types and their electrical recording. It features 2 cell culture compartments each having its own media and coating solutions, connected through 1 compartment for fluidic isolation. Each of the 3 channels has one inlet and one outlet. In the DuaLink architecture, the lateral channels (1 and 3) are symmetric and the central channel (2) is smaller to create a fluidic isolation compartment between them, enabling interaction while isolating the cellular compartment. Because of the micron scale of microchannels connecting channels, only cell extensions can develop in the microchannels, while cell bodies remain in the cell compartment (channels 1 and 3).
Thanks to the MicroElectrode Array (MEA) plate, develop in collaboration with Axion BioSystems, it is possible to record the electrical impact of compound on neurons somas or extensions. With 42 electrodes (white dots in the picture below) displayed both in the channels and microchannels, it is possible to record all neurons' parts: somas, axons and dendrites. It is also possible to monitor the propagation of an action potential from one channel to the other.
The electrophysiological recordings are performed thanks to Axion Biosystems' Maestro EDGE (8 chips per plate) instruments and results can be processed thanks to NETRI's Uplink software for easy interpretation of the collected data.
The plate comes in the EDGE format, displaying 8 independent designs (half-plate).
This technology is compatible with a wide range of readouts including ELISA, Live Staining, ImmunoFluorescence, Live/Dead Assays, Electrophysiology and more.
The DuaLink MEA platform can be used for compartmentalization & electrical activity recording, to model CIPN, to model neuromuscular junction or to analyze the functional impact of compound on organ via neurons electrical activity.
Specifications
| Parameters | Channel 1 | Channel 2 | Channel 3 |
| Length (µm) | 18 800 | 6000 | 18 800 |
| Width (µm) | 1 000 | 200 | 1 000 |
| Height (µm) | 200 | 200 | 200 |
| Volume (µL) | 3.8 | 0.24 | 3.8 |
| Volume with inlets/outlets (µm) | 117.7 | 114.1 | 117.7 |
| Surface area (mm²) | 18.8 | 1.2 | 18.8 |
| Surface area with inlets/outlets (mm²) | 32.9 | 15.3 | 32.9 |
| Microchannels | 125x6(±1)x3,2 µm ; LxWxH n=200; spaced by 20 µm | ||
| Material | Chip in PDMS, Structure in Polystyrene | ||
| Format | Standard ANSI 96-well plate | ||
| Shel-life | 4 months after reception | ||
Your Question Answered
View AllDarwin Microfluidics being based in France, ships orders under Delivered At Place (DAP) incoterms. This means that for customers outside the European Union (EU), you are responsible for any applicable customs fees, duties, and taxes in addition to the shipping costs. These charges are determined by your local customs authority and must be paid by you upon the arrival of the shipment in your country.
We recommend contacting your local customs office for detailed information on these charges if you're ordering from outside the EU, as they can vary depending on the destination and the value of your order. Please note that these additional costs are not included in the shipping fees charged by Darwin Microfluidics.
If you've received your order from Darwin Microfluidics and found that a product is defective or missing, please follow these steps to resolve the issue:
Report immediately: Contact our customer service team as soon as possible. Reporting the issue promptly helps us address your concern more efficiently.
Provide details: When you contact us, please provide your order number, the name the order was placed under, and a detailed description of the issue. For defective products, include clear photos or a video that shows the defect.
Review: Our team will review your claim to determine the best course of action. We may ask for additional information or details about the problem.
Resolution: Depending on the situation, we may send a replacement for the defective or missing item, provide a refund, or offer another satisfactory resolution. Our goal is to ensure you are completely satisfied with your purchase.
Follow-up: We will keep you updated throughout the process and confirm when the issue has been resolved to your satisfaction.
We apologize for any inconvenience caused by a defective or missing item and are committed to resolving your issue as quickly and smoothly as possible.
At Darwin Microfluidics, our goal is to offer the most competitive prices directly as our list price, ensuring that all our customers receive great value without needing to navigate complex discount structures. Here’s a detailed look at our discount policy:
Competitive list prices: We work hard to ensure our list prices are among the most competitive in the market. This approach allows us to offer fair pricing to all our customers from the start, eliminating the need for frequent discounts.
Quantity-based discounts: For certain products, we offer quantity-based discounts directly on the product pages. These discounts are automatically applied based on the quantity of the product you purchase, providing savings for bulk purchases without the need for special codes or negotiations.
Bulk orders: While we strive to offer the best prices upfront, we understand that customers making large-scale purchases may have special considerations. In such cases, we invite you to discuss your needs with our sales team. Depending on the size and nature of your order, we may be able to offer tailored discounts or pricing adjustments.
We believe in transparency and simplicity in pricing, allowing you to make your purchases with confidence, knowing you're receiving a fair deal without the hassle of negotiating discounts. If you have any questions about pricing or discounts for bulk orders, please don't hesitate to reach out to our sales team for personalized assistance.
Please follow our returns & refund page.
Since Darwin Microfluidics sells exclusively to companies and institutions and is based in France, the VAT treatment for your orders depends on the location of your company or institution:
Within the EU (excluding France): For customers in other EU countries, the reverse charge mechanism applies. This means that VAT is not charged by us at the point of sale. Instead, it is your responsibility to account for the VAT at the standard rate applicable in your country under the reverse charge procedure. This process helps simplify cross-border transactions within the EU.
In France: For customers located in France, standard French VAT rates apply to all purchases. As a France-based company, we are required to charge VAT on sales to other French companies and institutions, which you can then reclaim according to local VAT procedures if applicable.
Outside the EU: For customers outside the European Union, sales are not subject to VAT by us. However, you may be subject to import duties, taxes, and charges that are not included in the item price or shipping cost. These charges are the buyer's responsibility and vary by country. We advise checking with your local customs office for more information.
Please ensure your VAT identification number is provided during the ordering process for EU transactions to qualify for the reverse charge mechanism. If you have any questions regarding VAT charges or need further assistance with VAT-related issues, please contact our customer service team.
We are unable to provide specific estimates for customs fees, duties, or taxes associated with your order. These charges are determined by the customs authority in your country and can vary based on a variety of factors, including the type of items purchased, their value, and the country to which they are being shipped.
We recommend contacting your local customs office directly to get the most accurate and up-to-date information regarding potential customs charges for your order. They can provide you with detailed guidelines on the fees you might expect to pay based on the products you're importing from us.
Please remember, these charges are the responsibility of the recipient and are not included in the shipping costs paid to Darwin Microfluidics.
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