Designed for Clearer Results
SynVivo designed the SynBBB chip as a tool to provide researchers with a better model for studying the blood-brain barrier (BBB). Unlike traditional chips that complixify imaging and real-time visualization, SynBBB offers better clarity. With its circular architecture, it better replicates the hemodynamic conditions and morphology of in-vivo brain tissue. Its single layer design, with side-by-side channels recreates the blood-brain barrier, and offers a high level of precision for imaging. Your results will be easier to read, interpret, and trust.
A Co-Culture-Brain Assays with Endothelial cells/Astrocytes
IN-VIVO LIKE DESIGN
Morphologically accurate
brain tissues architecture
MICROFLUIDIC TECHNOLOGY
Controled conditions and low consumption of samples and reagents
ENHANCED READABILITY
Single layer chip with side-by-side channels architecture for better imaging
REAL-TIME INSIGHTS
Read cellular activity and
barrier activity instantly
ROBUST PROTOCOLS
Easy set-up and
designed for seamless use
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Real-Time Permeability Assays
Accurate and clear data is essential when evaluating drug permeability across the blood-brain barrier. The SynBBB’s side-by-side channels architecture allows for real-time visualization of drug transport across the barrier, offering you a clearer picture of how compounds interact with the BBB. Monitor drug behavior in real-time, and capture subtle changes in permeability that might be missed on other systems. The chip’s microfluidic technology consumes low volumes of reagent, ensuring that you get the most out of every sample.
Make your process more efficient without compromising the quality of your data!
Monoculture using Brain Endothelial cells/cell line
Brightfield image of Rhodamine 123 dye accumulation in the central compartment after 90min of perfusion in the BBB model without an inhibitor [a] and with an inhibitor [b].
[c] Comparison of fluorescent dye (Rho123) accumulation rate in the central compartment of BBB and BTB chips, after 90min of dye perfusion.
Fluorescent dye accumulation in BBB [d] and BTB [e] chips perfursed with Rho123 + P-gp inhibitors.
Biomarker Analysis
Tracking and quantifying biomarkers like tight junction or transporter proteins can be challenging if your imaging lacks clarity. The SynBBB single layer design simplifies this by providing better visualization, allowing you to see biomarker expressions clearly in real time. Enhanced readability ensures you can quickly identify and quantify important cellular markers without the need for complex post-processing. You can improve the quality of your results while speeding up your workflow, to make faster and more informed decisions during your BBB studies.
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Choose from different SynVivo micro-chips for your Starter Kit:
SynBBB features side-by-side channels that offer a more streamlined
and precise modeling of endothelial cells interactions across the blood-brain barrier.
Discover the documentation on SynVivo and the SynBBB microchip:
- SynVivo Presentation Brochure - View Brochure
- SynBBB Blood-Brain Barrier Model - View Brochure
- SynBBB 3D Model (Basic Configuration - Linear and Radial) - Technical Manual
- SynBBB 3D Model (TEER Configuration) - Technical Manual
Read the publications about the SynBBB 3D Blood-Brain Barrier Model:
- A microfluidic model of human brain (μHuB) for assessment of blood brain barrier. Brown TD, Nowak M, Bayles AV, et al. Bioeng Transl Med. 2019;4(2):e10126. Published 2019 Jan 13. doi:10.1002/btm2.10126
- In vitro blood brain barrier models: An overview. Jagtiani E, Yeolekar M, Naik S, Patravale V. J Control Release. 2022;343:13-30. doi:10.1016/j.jconrel.2022.01.011
- Permeability across a novel microfluidic blood-tumor barrier model. Terrell-Hall TB, Ammer AG, Griffith JI, Lockman PR. Fluids Barriers CNS. 2017;14(1):3. Published 2017 Jan 23. doi:10.1186/s12987-017-0050-9
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Visit our product page of the SynBBB 3D Blood Brain Barrier Model to get more details on chips specifications, content of the kits and documentation.