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TAMARA Nanoparticle Synthesis System

Streamline your Nanoparticle R&D with TAMARA: The Ultimate Plug-and-Play Microfluidics Solution.
TAMARA's user-friendly design supports volumes from microliters to over 10 milliliters, making it ideal for all development stages, from initial screening to in vivo studies. It provides precise control over nanoparticle size, polydispersity index (PDI), and encapsulation efficiency (EE%) for various nanoparticles, including RNA-LNP, liposomes, SLN, and PLGA, even for users with no prior experience.
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IT-TAMARA
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General

TAMARA is a microfluidic-based nanoparticle formulation system tailored for comprehensive research and development needs. It excels in nanoparticle formulation from initial screening through to in vitro and in vivo testing, managing volumes from 0.2 to 10 mL with exceptional repeatability. This allows consistent use throughout preclinical development without needing to reoptimize formulations.

User-Friendly Design

Developed by microfluidic experts, TAMARA simplifies nanoparticle synthesis. Beginners can synthesize nanoparticles in under two minutes by setting formulation parameters, loading samples, and pressing run. The integrated interface easily manages synthesis conditions, saving and loading runs.

Versatile for All R&D Stages

TAMARA supports all development phases with a single platform, transitioning smoothly from µL-scale screening to in vitro and in vivo testing. Its optimized design maximizes sample usage, even at very low volumes, minimizing losses.

Precision and Repeatability

Equipped with advanced microfluidic mixers, TAMARA offers a broad nanoparticle size range (50–400 nm), a Polydispersity Index (PDI) under 0.2, up to 97% encapsulation efficiency for RNA-LNP, and excellent batch-to-batch consistency (formulation dependant).

Broad Compatibility

TAMARA works with most non-polar solvents and various nanoparticle types, including polymer-based, lipid, and hybrid nanoparticles, making it ideal for encapsulating a wide range of payloads, from RNA and DNA to small drugs and ASOs.

Easy Maintenance & Reusability

Designed for optimal cleanability and reusability, TAMARA minimizes cross-contamination with components like PEEK reservoirs and thermoplastic microfluidic chips, ensuring reliable results with easy cleaning and sterilization.

Note: The guaranteed outcome is for the first run only. Chip's reusability depends on formulation and target volume.

Main features:

  • Consistent Results: Ensures batch-to-batch consistency and precise control over nanoparticle characteristics.
  • Efficient Reagent Use: Near-zero loss system maximizes reagent usage, reducing waste and optimizing resources.
  • Size Control: Easily achieve target nanoparticle sizes through user-friendly interface adjustments.
  • Low PDI: Produces homogeneous nanoparticle populations, crucial for efficacy and reduced toxicity.
  • High Encapsulation Efficiency: Achieves up to 97% encapsulation efficiency for a variety of payloads.

In summary, TAMARA is a versatile, easy-to-use platform for nanomedicine and LNP R&D, offering unparalleled control, repeatability, and application range, making it a valuable tool for researchers.

Content

1x TAMARA Controller

1x TAMARA Module

1x Reservoir

20x Microfluidic chips

Specifications

General

Dimensions Controller: 31 x 34 x 36 cm / 12.2 x 13.4 x 14.2 in
Synthesis module: 23 x 26 x 23 cm / 9.1 x 10.2 x 9.1 in
Weight Controller: 4.2 kg / 9.26 lbs
Synthesis module: 3.8 kg / 8.38 lbs
User Interface Touchscreen (800*480 px)

Operating Requirements

Electrical Power 110-220 V / 36 W
Gaz Pressure Input 8 to 10 bars
Only use dry and non-corrosive nor explosive gas
Operating Temperature 10 – 40°C

Synthesis Conditions

Inlet Volumes Depend on reservoir size
Achievable Volumes 0.2 - 10 mL
Total Flow Rate (TFR) 0.8 - 15 mL/min
Flow Rate Ratio (FRR) Solvent:Water 1:1 to 1:10
Initial Lipid Concentration Range 1 to 10 mg/mL
Chemical Compatibility Any aqueous buffers & polar solvent compatible with the wetted materials (Topas/COC and PEEK – e.g ethanol, methanol, etc.). See Topas and PEEK chemical compatibility here.
Material Loss < 10% or 50 µL (whichever higher)

Chip (consumables)

Material COC
Designs Herringbone and Baffled mixers

Reservoirs (consumables)

Material PEEK
Volume 0.2 - 3 mL or 1 - 30 mL (both can be combined)

Typical Expected Outcome

Nanoparticle Types Polymer and lipid-based nanoparticles (PLGA, RNA-LNP, SLN, Liposomes, etc.)
Payload* All RNA types, DNA, small molecules, peptides
Size Range* 50 – 300 nm
Batch to Batch Size Repeatability < 3%
PDI* < 0.2%
EE%* Up to 97% with RNA-LNP

*Formulation dependent

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