NanoCalibur Nanoparticle Formulation System
The NanoCalibur™ by MEPSGEN is an advanced microfluidic nanoparticle synthesis system designed for easy scalability. Engineered with cutting-edge microvortex mixing technology and parallelized microfluidic systems, NanoCalibur™ enables the formulation of nanoparticles, offering unmatched uniformity, efficiency, and biomolecular stability. NanoCalibur™ ensures reliable, high-performance synthesis.
General
The NanoCalibur™ Lab is a cutting-edge nanoparticle synthesis system designed for researchers and innovators working at the discovery and preclinical stages. Compact yet powerful, it offers precise control over nanoparticle formulation with advanced microfluidic technology, allowing users to produce highly uniform nanoparticles with exceptional efficiency. Featuring a user-friendly touchscreen interface and closed-loop feedback control, it simplifies lab-scale synthesis while maintaining the integrity of sensitive biomolecules.
Uniform Mixing and High Encapsulation Efficiency:
- Precisely engineered for uniform synthesis of nanoparticle (LNP, Liposome, Lipid-polymer or Lipid-protein)
- Uniform mixing with PDI ≤ 0.05
- 98% encapsulation efficiency (EE)
- Closed-loop feedback control for precise flow regulation and robust manufacturing
- Operates under consistent shear rates and maintains stability of biomolecules
Scalable Microfluidic Parallelization:
- Parallelized cartridge systems enable production up to 15 mL/min.
- Rotary multi-tube holder allows the simultaneous testing of multiple synthesis conditions in a single run
- Instruments for GMP-level production of nanoparticla for preclinical, clinical or commerical (up to 80 L/h) applications are under development
User-friendly:
- Touchscreen display for easy condition setting and monitoring.
- Cost-effective solution with stainless steel synthesis cartridges, reusable through auto-cleaning process in the system
Specifications
| Pressure | Operation Pressure | 5-7 bar |
| Flow control resolution | 0.1 mL/min | |
| Throughput | Total flow rate | 3-15 mL/min 0.2-1 L/h |
| Product per run | 0.5-100 mL/run | |
| Precursor Container | Aqueous phase | 50 mL * 1 |
| Organic phase | 50 mL * 1 | |
| Component | PS plastic tube + Silicone mold cap | |
| Product Container | Product & waste | 15 mL * 8 |
| Component | PS plastic tube | |
| General specifications | Dimensions (W x L x h) | 321.5 x 300 x 310 mm |
| Weight | Total 24 kg (Instrument: 22 kg, Display: 2 kg) | |
| Supply voltage | AC 100 V -240 V | |
| Power consumption | Max. 230 W |
Documentation
The NanoCalibur™ by MEPSGEN is an advanced microfluidic nanoparticle synthesis system designed for easy scalability. Engineered with cutting-edge microvortex mixing technology and parallelized microfluidic systems, NanoCalibur™ enables the formulation of nanoparticles, offering unmatched uniformity, efficiency, and biomolecular stability. NanoCalibur™ ensures reliable, high-performance synthesis.
General
The NanoCalibur™ Lab is a cutting-edge nanoparticle synthesis system designed for researchers and innovators working at the discovery and preclinical stages. Compact yet powerful, it offers precise control over nanoparticle formulation with advanced microfluidic technology, allowing users to produce highly uniform nanoparticles with exceptional efficiency. Featuring a user-friendly touchscreen interface and closed-loop feedback control, it simplifies lab-scale synthesis while maintaining the integrity of sensitive biomolecules.
Uniform Mixing and High Encapsulation Efficiency:
- Precisely engineered for uniform synthesis of nanoparticle (LNP, Liposome, Lipid-polymer or Lipid-protein)
- Uniform mixing with PDI ≤ 0.05
- 98% encapsulation efficiency (EE)
- Closed-loop feedback control for precise flow regulation and robust manufacturing
- Operates under consistent shear rates and maintains stability of biomolecules
Scalable Microfluidic Parallelization:
- Parallelized cartridge systems enable production up to 15 mL/min.
- Rotary multi-tube holder allows the simultaneous testing of multiple synthesis conditions in a single run
- Instruments for GMP-level production of nanoparticla for preclinical, clinical or commerical (up to 80 L/h) applications are under development
User-friendly:
- Touchscreen display for easy condition setting and monitoring.
- Cost-effective solution with stainless steel synthesis cartridges, reusable through auto-cleaning process in the system
Specifications
| Pressure | Operation Pressure | 5-7 bar |
| Flow control resolution | 0.1 mL/min | |
| Throughput | Total flow rate | 3-15 mL/min 0.2-1 L/h |
| Product per run | 0.5-100 mL/run | |
| Precursor Container | Aqueous phase | 50 mL * 1 |
| Organic phase | 50 mL * 1 | |
| Component | PS plastic tube + Silicone mold cap | |
| Product Container | Product & waste | 15 mL * 8 |
| Component | PS plastic tube | |
| General specifications | Dimensions (W x L x h) | 321.5 x 300 x 310 mm |
| Weight | Total 24 kg (Instrument: 22 kg, Display: 2 kg) | |
| Supply voltage | AC 100 V -240 V | |
| Power consumption | Max. 230 W |