INACCURATE TUMOR MODELS LIMIT YOUR RESEARCH?
Accelerate your research and get better accuracy with the SynTumor 3D Cancer Model. SynVivo’s vascularized microchip is engineered to replicate in-vivo conditions, for a real-time monitoring of Cancer, Stromal, Immune, and Vascular Cell Interactions.
SynTumor 3D Cancer Model
SynTumor offers a complex 3D tissue model designed to replicate a realistic tumor environment, enabling precise analysis of cell interactions and drug responses. It will provide you detailed insights into microvascular circulation, transport dynamics across vessel walls, and effective drug delivery. SynTumor allows researchers to closely simulate in vivo conditions while maintaining full control over experimental variables, facilitating more accurate and actionable data for oncology research.
Morphologically realistic
in-vivo architecture
Porous structures creating
physiological vasculature
Side by side architecture
for better imaging
Physiologically realistic
flow transport
Use of microfluidics for
low consumption of reagents
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Understand and Model Complex Microenvironments
SynTumor offers the ability to replicate and understand the complex environments of tumors and cancer cells. Using advanced microfluidic technology, it can model the intricate interactions between cancerous cells, vascular structures, and the tumor microenvironment in a 2D or 3D format. It allows the study of tumor behavior, progression, and responses to therapies. With a controlled and highly realistic setting, it bridges the gap between in vitro studies and clinical outcomes.
Tumor-Endothelial Interactions
in microvascular networks
Monitor Tumor Cells Behavior in Real-Time
SynTumor enables the real-time monitoring of phenotypic behaviors of tumor cells, and provides a dynamic view of cancer cells interactions in their microenvironment. Its side-by-side channel configuration allow for better imaging results and a continuous observation. You can easily track cellular responses and morphological changes, and monitor the progression of the disease. Identifying key factors influencing tumor growth and metastasis, would lead the way to more targeted and effective therapeutic solutions.
Left: Highly Metastatic Tumor. Right: Non-metastatic Tumor.
A metastatic tumor rapidly spread to adjacent chambers (left) while non-metastatic tumor does not (right).
Insert image shows stained images highlighting elongated protrusions for metastatic tumor in contrast to localized for non-metastatic tumor.
Easily Assess Drug Delivery, Efficacy, and Toxicity
SynVivo’s unique microchip design with a vascularized structure mimics the natural delivery pathways of the human body. It allows you to evaluate how drugs penetrate and affect tumor tissues in a more realistic setting. This precise design, modeled on real human-vascular system patterns, ensure higher fidelity on drug interactions, effectiveness, and potential side effects. SynTumor's ability to mimic the in-vivo complexities results in more reliable preclinical data, accelerating the development of safer and more effective cancer treatments.
Screening of polymers for gene delivery accurately reproduces in vivo responses (candidate A and B both perform well when directly injected into tumor, while under vascular injection candidate A performs well and candidate B performs poorly).
Ready to accelerate your research?
Choose from different SynVivo micro-chips
SynTumor features side-by-side channels that offer a more streamlined
and precise modeling of tumor-vascular interactions.
Idealized Co-Culture Network Chips
(IMN2 Linear)
Idealized Co-Culture Network Chips
(IMN2 Radial)
Don't waste any more resources, get higher accuracy in your results!
SynTumor’s innovative vascularized design accurately replicates cell interactions, ensuring that your research reflects real biological responses. Reducing experimental variability and enhancing the reliability of your data allows for more predictive results.
Get confident with your findings and let your research advance faster!
Discover the documentation on SynVivo and the SynTumor microchip:
Read the publications about the SynTumor 3D Cancer Model:
- Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model - ACS Appl. Nano Mater. 2019, 2, 4, 1844–1856
- A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy - Pradhan, S., Smith, A.M., Garson, C.J. et al. Sci Rep 8, 3171 (2018).
- A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems - Tang, Y., Soroush, F., Sheffield, J.B. et al. Sci Rep 7, 9359 (2017).
- Microfluidic co-culture devices to assess penetration of nanoparticles into cancer cell mass - Jarvis M, Arnold M, Ott J, Pant K, Prabhakarpandian B, Mitragotri S. Bioeng Transl Med. 2017 Sep 26;2(3):268-277. doi: 10.1002/btm2.10079. PMID: 29313036; PMCID: PMC5689499.
Want to know more on this product?
Visit our product page of the SynTumor 3D Cancer Model to get more details on chips specifications, content of the kits and documentation.
