Idealized Network for co-culture - IMN2 radial chips
- Product SKU: SY-102009
- Category: Microfluidic Chips, Microfluidic Organ-on-a-chip, Organ-on-a-chip Chips, SynVivo
These idealized co-culture designs are helpful tools in the organ-on-chip field to mimic cellular interactions in vitro. This design is composed of a central chamber surrounded by two outer channels, allowing the modeling of a wide range of cell-cell interactions.
The IMN2 Radial organ-on-chip design is made of a central chamber (tissue chamber) and two outer channels. This side-by-side architecture enables the co-culture of different cell types with real-time visualization. These platforms allow the modeling of physiological shear stress and in vivo-like morphology of tissues.
The separation between the central and outer channels can be done with either slits or pillars and are available in several dimensions. In both cases, slits/pillars are spaced at regular intervals to create a barrier between the inner and outer chambers.
These designs can be used in a wide range of applications: modeling of tumors (SynTumor), studies on inflammation processes (SynRAM), toxicology studies (SynTox), or modeling of the blood-brain barrier (SynBBB). For the latter one, a version including TEER measurement is also available to measure electrical resistance for non-invasive barrier assessment. You can refer to the specific product pages of those applications for more information and protocols.
3x IMN2 Radial chips
The chips have the format of a microscopic slide and are made of PDMS bonded to glass.
|Outer channel (µm)||100||200||200||
|Slit/pillar spacing S (µm)||100||50||50||50||50||50|
|Slit width Ws (µm)||2||3||3||3||2||2|
|Pillar height (µm)||-||-||-||-||-||-|
|Travel T (µm)||50||50||100||50||50||100|
|Examples of applications||
|Chips from starter/assay kits||Yes||Yes||-||Yes||Yes||-|
|Outer channel (µm)||200||200||200||200||200||200|
|Slit/pillar spacing S (µm)||3
|Slit width Ws (µm)||-||-||-||-||-||-|
|Pillar height (µm)||3||3||3||3||8||8|
|Travel T (µm)||100||50
|Examples of applications||SynRAM
|Chips from starter/assay kits||-||Yes||-||-||-||Yes|
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