Idealized Network for co-culture - IMN2 radial chips
- Product SKU: SY-102009
- Category: Microfluidic Chips, Microfluidic Organ-on-a-chip, Organ-on-a-chip Chips, SynVivo
These idealized co-culture designs are helpful tools in the organ-on-chip field to mimic cellular interactions in vitro. This design is composed of a central chamber surrounded by two outer channels, allowing the modeling of a wide range of cell-cell interactions.
The IMN2 Radial organ-on-chip design is made of a central chamber (tissue chamber) and two outer channels. This side-by-side architecture enables the co-culture of different cell types with real-time visualization. These platforms allow the modeling of physiological shear stress and in vivo-like morphology of tissues.
The separation between the central and outer channels can be done with either slits or pillars and are available in several dimensions. In both cases, slits/pillars are spaced at regular intervals to create a barrier between the inner and outer chambers.
These designs can be used in a wide range of applications: modeling of tumors (SynTumor), studies on inflammation processes (SynRAM), toxicology studies (SynTox), or modeling of the blood-brain barrier (SynBBB). For the latter one, a version including TEER measurement is also available to measure electrical resistance for non-invasive barrier assessment. You can refer to the specific product pages of those applications for more information and protocols.
3x IMN2 Radial chips
The chips have the format of a microscopic slide and are made of PDMS bonded to glass.
With slits:
| SY-102004 | SY-102005 | SY-102006 | SY-102015 (TEER) | SY-102016 | SY-102017 | |
| Outer channel (µm) | 100 | 200 | 200 |
200 |
200 | 200 |
| Barrier type | Slits | Slits | Slits |
Slits | Slits | Slits |
| Slit/pillar spacing S (µm) | 100 | 50 | 50 | 50 | 50 | 50 |
| Slit width Ws (µm) | 2 | 3 | 3 | 3 | 2 | 2 |
| Pillar height (µm) | - | - | - | - | - | - |
| Travel T (µm) | 50 | 50 | 100 | 50 | 50 | 100 |
| Depth (µm) | 100 | 100 | 100 | 100 | 100 | 100 |
| Examples of applications |
SynTumor |
SynBBB | SynTumor | SynBBB-TEER | SynTox | SynTox |
| Chips from starter/assay kits | Yes | Yes | - | Yes | Yes | - |
With pillars:
| SY-102007 | SY-102008 | SY-102009 | SY-102010 | SY-102011 | SY-102012 | |
| Outer channel (µm) | 200 | 200 | 200 | 200 | 200 | 200 |
| Barrier type | Pillars |
Pillars | Pillars | Pillars | Pillars | Pillars |
| Slit/pillar spacing S (µm) | 3 |
8 | 3 | 8 | 3 | 8 |
| Slit width Ws (µm) | - | - | - | - | - | - |
| Pillar height (µm) | 3 | 3 | 3 | 3 | 8 | 8 |
| Travel T (µm) | 100 | 50 |
50 | 100 | 100 | 50 |
| Depth (µm) | 100 | 100 | 100 | 100 | 100 | 100 |
| Examples of applications | SynRAM |
SynRAM |
SynRAM | SynRAM | SynRAM | SynTumor |
| Chips from starter/assay kits | - | Yes | - | - | - | Yes |
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