The Fluidic 219 Organ-on-a-Chip by Microfluidic ChipShop provides an affordable and compact method for replicating biological barriers in vitro. Each chip features four open culture chambers, allowing direct access to the membrane area.
The chip is fabricated in Topas (COC, cyclic olefin copolymer) for better light transmittance. The inlets and outlets with integrated Mini Luer connections ensure leak-free junctions with the tubing and allow experiments under dynamic flow conditions.
General
This Organ-on-a-Chip allows you to reliably mimic physiological conditions in vitro and study tissue organization, cell-cell interactions, barrier penetration, and physiological responses in a more in vivo-like environment.
These open chips have been designed to allow direct access to membrane areas and provide a permanent entry port for liquid supply, storage, and exchange.
This chip is designed to develop models of physiological barriers and to ensure an in vivo-like environment under static or dynamic flow conditions. Each chamber has 2 mini Luer connection ports to supply the bottom compartment, below the membrane. In combination with matching interaction tanks for liquid supply and storage, this chip allows for a wide variety of filtering and assay tasks.
The entire body of the chip is made of Topas, a cyclic olefin copolymer (COC) to overcome the limitations of standard PDMS. Topas does not unspecifically absorb medium contents and has high stability and ideal optical characteristics for the bright field as well as fluorescence microscopy. Topas is frequently used in medical devices due to its proven biocompatibility.
Each chamber offers an 8 µm porous membrane.
Features
- Mini Luer connection molded with the chip: leak-free
- Highly resistant and optically clear material: Topas (COC, cyclic olefin copolymer) has high transparency (equivalent to glass) and very low grade of auto-fluorescence
- Standard microscope glass slide size (75.5 mm x 25.5 mm x 1.5 mm)
- Cover lid thickness: 140 µm
- 8 µm porous PET membrane
Content
1x Open membrane organ-on-a-chip with mini Luer ports
Specifications
| Chip material |
Topas (COC) |
| Membrane material |
PET |
| Pore size (µm) |
8 |
| Lid thickness (µm) |
140 |
Documentation
Click to read more information about ChipShop chips material properties.
Maurer, M., Gresnigt, M. S., Last, A., Wollny, T., Berlinghof, F., Pospich, R., ... & Mosig, A. S. (2019). A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials,220, 119396. https://doi.org/10.1016/j.biomaterials.2019.119396
Raasch, M., Rennert, K., Jahn, T., Peters, S., Henkel, T., Huber, O., ... & Mosig, A. (2015). Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication, 7(1), 015013. doi:10.1088/1758-5090/7/1/015013
Rennert, K., Steinborn, S., Gröger, M., Ungerböck, B., Jank, A. M., Ehgartner, J., Nietzsche, S., Dinger, J., Kiehntopf, M., Funke, H., Peters, F. T., Lupp, A., Gärtner, C., Mayr, T., Bauer, M., Huber, O., & Mosig, A. S. (2015). A microfluidically perfused three dimensional human liver model. Biomaterials, 71, 119–131. https://doi.org/10.1016/j.biomaterials.2015.08.043
