The TriaLink NeoBento™ features 8 or 16 chips per plate. The TriaLink architecture has been specially designed to create fluidic isolation and co-culture up to 3 cell types. All channels are connected by microchannels to allow 3 independant cell culture. Neurons are used as bio-sensors, cell bodies growing in one channel and extensions in microchannels to reach and innervate any organs cultivated in the opposite channel.
The NeuroFluidics Line by NETRI is fabricated in PDMS for high transparency and biocompatibility. This technology is ideal for developing high-throughput organ-on-a-chip models to accelerate drug development and disease modeling.
General
NETRI’s NeuroFluidics Devices are innovative organ-on-a-chip platforms for organ modeling and drug discovery. They offer high-throughput data collection with up to 16 data points on the same plate. With their pump-free design and standard ANSI 96-well plate format, they can be seamlessly integrated with standard lab equipment and are compatible with a wide range of readouts for in-depth data analysis. NETRI’s platforms aim to model a wide range of organs and use neurons as bio-sensors to innervate those organs.
The TriaLink design of the NeuroFluidics Devices allows the culture of up to 3 cell types. It features 3 cell culture compartments each having its own media and coating solutions. Each of the 3 channels has one inlet and one outlet. Because of the micron scale of microchannels connecting channels, only cell extensions can develop in the microchannels, while cell bodies remain in the cell compartment (channels 1,2,3).
There are two formats available:
- LIGHT: to perform up to 8 individual experiments simultaneously (half-plate)
- FULL: to perform up to 16 individual experiments simultaneously (full plate)
The technology is compatible with a wide range of readouts including ELISA, Live Staining, ImmunoFluorescence, Live/Dead Assays and more.
The TriaLink platform can be used for a wide variety of applications including cell migration, chemotaxis, neuroinflammation modelling, gut-brain axis modelling and many other applications.
Content
1x TriaLink LIGHT or FULL
Specifications
| Parameters |
Channel 1 |
Channel 2 |
Channel 3 |
| Length (µm) |
17 200 |
6000 |
17 200 |
| Width (µm) |
1 000 |
1000 |
1 000 |
| Height (µm) |
200 |
200 |
200 |
| Volume (µL) |
3.4 |
1.2 |
3.4 |
| Volume with inlets/outlets (µm) |
117.3 |
115.1 |
117.3 |
| Surface area (mm²) |
17.2 |
6 |
17.2 |
| Surface area with inlets/outlets (mm²) |
31.34 |
15.34 |
32.9 |
| Microchannels |
450x6(±1)x3,4 µm ; LxWxH n=200; spaced by 20 µm |
| Material |
Chip in PDMS, Structure in Polystyrene |
| Format |
Standard ANSI 96-well plate |
| Shel-life |
4 months after reception |
Documentation
TriaLink technical specifications
Application note - Improve reproducibility
Application note - Surface tension-based cell seeding
