EXTENDO 944X
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SynBBB 3D Blood Brain Barrier Physiologically accurate
A more Accurate Model for Better Research
The SynBBB microchip offers a unique, physiologically accurate model of the blood-brain barrier. With its realistic circular architecture and flow conditions, the SynBBB chip closely mimics the in-vivo environment.
Unlike conventional models, which often fail to replicate the complex dynamics of the blood-brain barrier, SynBBB allows for better simulation of physiological conditions, leading to results that are more reflective of actual biological processes. SynVivo’s technology aim to give researchers more trustworthy data.
Assay of Co-Culture-Brain with Endothelial cells/Astrocytes
IN-VIVO LIKE DESIGN
Morphologically accurate
brain tissues architecture
PHYSIOLOGICAL FLOW
Controled conditions simulating
natural fluid transport
POROUS ARCHITECTURE
Slits to model barrier function
and cell interactions
REALISTIC HEMODYNAMICS
Accuratly model shear
stress conditions
CONTROLED FLUIDS USAGE
Low samples and reagents usage
for cost-effective experiment
Make your research come to life!
Experience more accurate and physiologically relevant data with SynBBB.
A distributor trusted by your peers
Get closer to in-vivo conditions for more realistic results
Neuroprotection Studies
Testing neuroprotective drugs requires a blood-brain barrier model that truly reflects in-vivo conditions. Based on a real brain-tissues, the SynBBB's realistic architecture and physiological flow allow you to evaluate drug effects in a better controlled environment. By closely replicating actual BBB conditions, SynBBB helps you measure the protective potential of compounds against neurodegeneration. So you get results that you can translate more effectively to real-world applications.
NeuroOncology
Studying the interaction between tumor cells and the blood-brain barrier demands a physiologically accurate model. SynBBB's in-vivo-like architecture and realistic flow create the conditions you need to investigate how tumor cells infiltrate the BBB. You will be able to evaluate more precisely potential therapeutic interventions. Accurate simulation in earlier stage helps you better understand cancer's progression in the brain and develop more effective treatments targeting the BBB.
Real-time immunofluorescence images of blood-brain-tumor barrier setup (BBTB-on-chip) using the SynBBB chip.
[Phase contrast image] iBECs seeded in the middle channel.
[Red] U87vIII-mKate2 cells seeded in outer channels.
[Green] CAR-F263 perfusion can be seen within the middle iBEC channel.
Bridge the gap between your lab and real biology.
Get more accurate results with SynBBB, so you can focus on the science, not the guesswork.
Select from various Idealized Co-Culture Network Chips type:
SynBBB includes side-by-side channels that offer a more physiologically accurate model
for studying endothelial cells interactions across the blood-brain barrier.
Discover the documentation on SynVivo and the SynBBB microchip:
- SynVivo Presentation Brochure - View Brochure
- SynBBB Blood-Brain Barrier Model - View Brochure
- SynBBB 3D Model (Basic Configuration - Linear and Radial) - Technical Manual
- SynBBB 3D Model (TEER Configuration) - Technical Manual
Read the publications about the SynBBB 3D Blood-Brain Barrier Model:
- A microfluidic model of human brain (μHuB) for assessment of blood brain barrier. Brown TD, Nowak M, Bayles AV, et al. Bioeng Transl Med. 2019;4(2):e10126. Published 2019 Jan 13. doi:10.1002/btm2.10126
- In vitro blood brain barrier models: An overview. Jagtiani E, Yeolekar M, Naik S, Patravale V. J Control Release. 2022;343:13-30. doi:10.1016/j.jconrel.2022.01.011
- Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies. Huang J, Li YB, Charlebois C, et al. Fluids Barriers CNS. 2022;19(1):38. Published 2022 Jun 1. doi:10.1186/s12987-022-00342-y
- Trastuzumab distribution in an in-vivo and in-vitro model of brain metastases of breast cancer Terrell-Hall TB, Nounou MI, El-Amrawy F, Griffith JIG, Lockman PR. Oncotarget. 2017;8(48):83734-83744. Published 2017 Jul 26. doi:10.18632/oncotarget.19634
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Browse our product page of the SynBBB 3D Blood Brain Barrier Model to get more informations on chips specifications, content of the kits and documentation.
