NanoCalibur Nanoparticle Formulation System
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MP-NANOCALIBUR
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The NanoCalibur™ by MEPSGEN is an advanced microfluidic nanoparticle synthesis system designed for easy scalability. Engineered with cutting-edge microvortex mixing technology and parallelized microfluidic systems, NanoCalibur™ enables the formulation of nanoparticles, offering unmatched uniformity, efficiency, and biomolecular stability. NanoCalibur™ ensures reliable, high-performance synthesis.
General
The NanoCalibur™ Lab is a cutting-edge nanoparticle synthesis system designed for researchers and innovators working at the discovery and preclinical stages. Compact yet powerful, it offers precise control over nanoparticle formulation with advanced microfluidic technology, allowing users to produce highly uniform nanoparticles with exceptional efficiency. Featuring a user-friendly touchscreen interface and closed-loop feedback control, it simplifies lab-scale synthesis while maintaining the integrity of sensitive biomolecules.
Uniform Mixing and High Encapsulation Efficiency:
- Precisely engineered for uniform synthesis of nanoparticle (LNP, Liposome, Lipid-polymer or Lipid-protein)
- Uniform mixing with PDI ≤ 0.1 (LNP) and PDI ≤ 0.2 (Liposome)
- Encapsulation efficiency (EE) > 90%, up to 98%
- Closed-loop feedback control for precise flow regulation and robust manufacturing
- Operates under consistent shear rates and maintains stability of biomolecules
Scalable Microfluidic Parallelization:
- Parallelized cartridge systems enable production from 2.5 to 20 mL/min (0.15 to 1 L/h)
- Rotary multi-tube holder allows the simultaneous testing of multiple synthesis conditions in a single run
- GMP-level instruments for nanoparticle production (up to 6 L/h) are now commercially available and suitable for use in preclinical toxicology and efficacy studies, as well as early-phase clinical trials
User-friendly:
- Touchscreen display for easy condition setting and monitoring.
- Cost-effective solution with stainless steel synthesis cartridges, reusable through auto-cleaning process in the system and waste volume discharge
Specifications
| Pressure | Operation pressure | 4 bar |
| Flow control resolution | 0.1 mL/min | |
| Throughput | Total flow rate | 2.5 - 20 mL/min 0.15 - 1 L/h |
| Product per run | 3 - 90 mL | |
| Precursor Container | Aqueous phase | 50 mL |
| Organic phase | 50 mL | |
| Product Container | Product & waste | 15 mL |
| General specifications | Dimensions (W x L x h) | 32 x 32 x 31 cm |
| Weight | Total 27 kg (Instrument: 25 kg, Display: 2 kg) | |
| Supply voltage | AC 100 V -240 V | |
| Power consumption | Max. 230 W | |
| Formulation information of precursors | Total lipid concentration | 0.6 - 13 mg/mL |
| Nucleic acid concentration | 0.004 - 0.3 mg/mL | |
| Minimum amount of initial mRNA | 0.007 mg | |
| Encapsulation efficiency | > 90 % | |
Documentation
products.product_description_title
+
The NanoCalibur™ by MEPSGEN is an advanced microfluidic nanoparticle synthesis system designed for easy scalability. Engineered with cutting-edge microvortex mixing technology and parallelized microfluidic systems, NanoCalibur™ enables the formulation of nanoparticles, offering unmatched uniformity, efficiency, and biomolecular stability. NanoCalibur™ ensures reliable, high-performance synthesis.
General
The NanoCalibur™ Lab is a cutting-edge nanoparticle synthesis system designed for researchers and innovators working at the discovery and preclinical stages. Compact yet powerful, it offers precise control over nanoparticle formulation with advanced microfluidic technology, allowing users to produce highly uniform nanoparticles with exceptional efficiency. Featuring a user-friendly touchscreen interface and closed-loop feedback control, it simplifies lab-scale synthesis while maintaining the integrity of sensitive biomolecules.
Uniform Mixing and High Encapsulation Efficiency:
- Precisely engineered for uniform synthesis of nanoparticle (LNP, Liposome, Lipid-polymer or Lipid-protein)
- Uniform mixing with PDI ≤ 0.1 (LNP) and PDI ≤ 0.2 (Liposome)
- Encapsulation efficiency (EE) > 90%, up to 98%
- Closed-loop feedback control for precise flow regulation and robust manufacturing
- Operates under consistent shear rates and maintains stability of biomolecules
Scalable Microfluidic Parallelization:
- Parallelized cartridge systems enable production from 2.5 to 20 mL/min (0.15 to 1 L/h)
- Rotary multi-tube holder allows the simultaneous testing of multiple synthesis conditions in a single run
- GMP-level instruments for nanoparticle production (up to 6 L/h) are now commercially available and suitable for use in preclinical toxicology and efficacy studies, as well as early-phase clinical trials
User-friendly:
- Touchscreen display for easy condition setting and monitoring.
- Cost-effective solution with stainless steel synthesis cartridges, reusable through auto-cleaning process in the system and waste volume discharge
Specifications
| Pressure | Operation pressure | 4 bar |
| Flow control resolution | 0.1 mL/min | |
| Throughput | Total flow rate | 2.5 - 20 mL/min 0.15 - 1 L/h |
| Product per run | 3 - 90 mL | |
| Precursor Container | Aqueous phase | 50 mL |
| Organic phase | 50 mL | |
| Product Container | Product & waste | 15 mL |
| General specifications | Dimensions (W x L x h) | 32 x 32 x 31 cm |
| Weight | Total 27 kg (Instrument: 25 kg, Display: 2 kg) | |
| Supply voltage | AC 100 V -240 V | |
| Power consumption | Max. 230 W | |
| Formulation information of precursors | Total lipid concentration | 0.6 - 13 mg/mL |
| Nucleic acid concentration | 0.004 - 0.3 mg/mL | |
| Minimum amount of initial mRNA | 0.007 mg | |
| Encapsulation efficiency | > 90 % | |
Documentation
products.specification
+
short_description
The NanoCalibur™ by MEPSGEN is an advanced microfluidic nanoparticle synthesis system designed for easy scalability.
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