BFlow

Bifurcated Vessel-on-a-chip

Add Your Review

Product SKU: BF-B01_0025
Category: BFlow, Microfluidic Chips, Microfluidic Organ-on-a-chip, New Products, Organ-on-a-chip Chips

This organ-on-a-chip design models a "vessel" bifurcation, a key element in endothelium biology and the onset of cardiovascular diseases. This device accurately mimics vascular geometries and physiological flow associated.

Average lead time: 2 weeks

€195.00

Quantity

This organ-on-a-chip design models a "vessel" bifurcation, a key element in endothelium biology and the onset of cardiovascular diseases. This device accurately mimics vascular geometries and physiological flow associated.

This "vessel-on-a-chip" system is ideal for gaining insight into vascular biology by modeling blood vessel geometry associated with a physiological flow of medium, cells, and/or particles or interest. The Y bifurcation exists with different options of bifurcation angles but also channel section types (semicircular or circular) and diameters. Bifurcation angle can be set up at 45°, 90°, or 135° allowing the study of a wide range of vascular geometries.

The circular channels enhance the physiological resemblance of the model to the human body to better decipher biological phenomena and test molecules.

These organ-on-chips devices are sold in packs of 3 chips with one Y design on each chip. The devices are made of PDMS and glass and are thus, autoclavable, biocompatible, gas permeable, and can be imaged with high optical quality.

3x bifurcated chips

Chips with bifurcation angle of 45°

SKU	B01_0025	B06_0022	B06_0019	B06_0016
Bifurcation angle (°)	45
Channel diameter (mm)	1		2
Section shape	Semicircular	Circular	Semicircular	Circular
Inlet diameter (mm)	3
Inlet volume (µL)	4.5	9	4.5	9
Channel volume (µL)*	25.8	51.5	51.5	103
Channel length (mm)**	32.8
Chip thickness (mm)	5.5	6.5	5.5	6.5

Chips with bifurcation angle of 90°

SKU	B01_0024	B06_0021	B06_0018	B06_0015
Bifurcation angle (°)	90
Channel diameter (mm)	1		2
Section shape	Semicircular	Circular	Semicircular	Circular
Inlet diameter (mm)	3
Inlet volume (µL)	4.5	9	4.5	9
Channel volume (µL)*	24.4	48.7	48.7	97.4
Channel length (mm)**	31.9
Chip thickness (mm)	5.5	6.5	5.5	6.5

Chips with bifurcation angle of 135°

SKU	B01_0025	B06_0022	B06_0019	B06_0016
Bifurcation angle (°)	135
Channel diameter (mm)	1		2
Section shape	Semicircular	Circular	Semicircular	Circular
Inlet diameter (mm)	3
Inlet volume (µL)	4.5	9	4.5	9
Channel volume (µL)*	22.8	45.3	45.3	91
Channel length (mm)**	28
Chip thickness (mm)	5.5	6.5	5.5	6.5

* Channel volume = central channel + two branches

** Channel length = central channel + one branch

Chip material: PDMS, a biocompatible silicone, optically compatible, oxygen breathable and autoclavable at 121°C.

Find presentation and explanatory videos of BFlow products here.

Turpin C., Apalama M.L., Carnero B., Otero-Cacho A., Munuzuri A.P., Flores-Arias M.T., Vélia E., Meilhac O., Bourdon E., Alvarez E., Rondeau P. (2019). Impact of enhanced phagocytosis of glycated erythrocytes on human endothelial cell functions. Cells, 2(4), 1844-1856. https://doi.org/10.3390/cells11142200

Casa-Arozamena C., Otero-Cacho A., Carnero R., Almenglo C., Aymerich M., Alonso-Alconada L., Ferreiros A., Abalo A., Bao-Varela C., Flores-Arias M.T., Alvarez E., Munuzuri A.P., Abal M. (2021). Heemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis. Scientific Reports, 2(4), 1844-1856. https://doi.org/10.1038/s41598-021-02482-x

Otero-Cacho A., Aymerich M., Flores-Arias M.T., Abal M., Alvarez E., Perez-Munuzuri V., Munuzuri A.P. (2018). Determination of hemodynamic risk for vascular disease in planar artery bifurcations. Scientific Reports, 2(4), 1844-1856. https://doi.org/10.1038/s41598-018-21126-1

Payment Terms

You can either order and pay via credit card or invoice (through a purchase order). Request a quote easily by clicking on the "Request a Quote" button in the cart page.

Please note that some products are not available for direct purchase: just click "Request a Quote" on the product page and fill in the form to get more informations!

Credit card

Add your products to the cart
In the cart page, click on Proceed to Checkout
Complete your credit card informations (don't worry, we are using Stripe, a PCI-certified program specialized in online transactions)
That's it! You will receive an order confirmation within a few minutes, and our team will send you the invoice.

Invoice

Add your products to the cart
In the website header, click on Request a Quote
Fill in the required informations, then click on Submit Quote
Our team will send you a quote shortly
After receiving the quote, just send your purchase order at contact@darwin-microfluidics.com
Our team will complete your purchase and send you the invoice!

If you wish to pay in USD, GBP or AUD, please specify it in your PO. We can add the converted value in the required currency to the quote if requested.

Worldwide shipping

We ship worldwide from our warehouse in France.

Shipping charges are calculated based on the shipping country, and can be estimated from the cart page. Our shipping rates and times are:

France: GLS (1-2 business days), free shipping above 350€
Germany, Austria, Belgium, Denmark, Spain, Hungary, Italy, Luxembourg, Netherlands, Poland, Portugal, Czechia, Slovakia:

GLS (2-4 business days), free shipping above 350€
DHL Express (1-2 business days), reduced rate above 350€

Bulgaria, Croatia, Estonia, Finland, Ireland, Latvia, Lithuania, Romania, Slovenia, Sweden, Greece, Cyprus, Malta: DHL Express (1-2 business days), free shipping above 400€
United Kingdom: DHL Express (1-2 business days), free shipping above 400€
USA, Canada: DHL Express (1-3 business days), free shipping above 400€
Switzerland: DHL Express (1-2 days), free shipping above 450€
Other countries: DHL Express, shipping rates based on the destination, weight and dimensions

If you wish to use your own shipping account, we will charge a flat fee of 15€.

We reserve the right to apply a surcharge for parcels > 30 kg, palletized shipments, or packages with dimensions exceeding the maximum dimensions of our carriers.

Please note that our standard shipping incoterms are DAP (Delivered At Place), or EXW if using your own carrier.