This organ-on-a-chip provides 3 bifurcation designs on one chip to mimic blood vessels. This is particularly interesting for the study of endothelium biology through a physiological model. This system is designed to study the local flow conditions at the bifurcation.
General
With 3 bifurcation designs in one system, this organ-on-chip is ideal for performing parallel experiments modeling blood vessel geometry associated with a physiological flow of medium, cells, and/or particles or interest. The Y bifurcation design comes with a bifurcation angle of 90° and fully circular channels for more physiological modeling.
These organ-on-chips devices are sold in packs of 3 chips with 3 Y designs on each chip. The chips are made of PDMS and glass and are thus, autoclavable, biocompatible, gas permeable, and can be imaged with high optical quality.
Content
3x multi-bifurcated chips with 3 Y designs per chip
Specifications
| SKU |
B01_0027 |
| Bifurcation angle (°) |
90 |
| Channel diameter (mm) |
3 |
| Section type |
Circular |
| Inlet diameter (mm) |
3 |
| Inlet volume (µL) |
7 |
| Channel volume (µL)* |
14.9 |
| Channel length (mm)** |
15.9 |
| Chip thickness (mm) |
6.5 |
* Channel volume = central channel + two branches
** Channel length = central channel + one branch
Chip material: PDMS, a biocompatible silicone, optically compatible, oxygen breathable and autoclavable at 121°C.
Documentation
Find presentation and explanatory videos of BFlow products here.
Turpin C., Apalama M.L., Carnero B., Otero-Cacho A., Munuzuri A.P., Flores-Arias M.T., Vélia E., Meilhac O., Bourdon E., Alvarez E., Rondeau P. (2019). Impact of enhanced phagocytosis of glycated erythrocytes on human endothelial cell functions. Cells, 2(4), 1844-1856. https://doi.org/10.3390/cells11142200
Casa-Arozamena C., Otero-Cacho A., Carnero R., Almenglo C., Aymerich M., Alonso-Alconada L., Ferreiros A., Abalo A., Bao-Varela C., Flores-Arias M.T., Alvarez E., Munuzuri A.P., Abal M. (2021). Heemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis. Scientific Reports, 2(4), 1844-1856. https://doi.org/10.1038/s41598-021-02482-x
Otero-Cacho A., Aymerich M., Flores-Arias M.T., Abal M., Alvarez E., Perez-Munuzuri V., Munuzuri A.P. (2018). Determination of hemodynamic risk for vascular disease in planar artery bifurcations. Scientific Reports, 2(4), 1844-1856. https://doi.org/10.1038/s41598-018-21126-1
