EXTENDO 944X
EXTENDO 944X Featuring several next gen optimizations, the Extendo 944X telehandler is powered by a standard
Akura Twin Starter Package
The Akura™ Twin platform has been designed to study organ-organ interactions. With 192 conditions on a single plate, the platform gives access to high-throughput spheroid crosstalk studies. The wells display a proprietary design to enable improved medium exchange while avoiding spheroid loss. Long-term maintenance of spheroids and a wide range of readouts are made possible to ensure high-quality experiments. This Starter Package includes everything needed to get started with the Akura™ Twin technology.
- Product SKU:
- IS-CS-KE11
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General
The Akura™ Twin plate follow the format of a 384-well Akura™ plate except that two adjacent wells are connected via a micofluidic channel. Each well can contain one spheroid/organoid and provide a 1 mm diameter window to easily spot and observe the tissues. The wells also display the SureXchange ledge technology from InSphero allowing almost complete (> 90%) medium exchange and reducing drastically spheroid loss. Only a minimal residual volume of 8-10 µL is left after medium retrieval, avoiding dilution of metabolites and molecules of interest contained in the supernatant and enhancing dosing precision. The surface is coated to be cell-repellent, preventing cellular adhesion and maintaining spheroid strucutre for long-term culture.
Each plate hence displays 192 Twin units allowing co-culture of different tissues. Among those units, some are perpendicular to other, and cosntitue "no-flow" conditions to be used as controls during experiments to easily compare dynamic vs static models.
This Akura™ Twin platform allows high-throughput study of spheroid-spheroid cross-talk but also interaction of spheroids with additional circulating cells like immune cells. Those cells, as well as, nutrients or signaling molecules, can circulate from one spheroid to the other through the 4.5 mm microfluidic channel enabling active tissue-tissue cross-talk and cell migration. A gravity-based flow between the two wells of a Twin unit is established thanks to the Akura™ Flow Programmable All-in-One Tilter.
While being very innovative, this platform follow the ANSI/SLAS standard format for easy integration in automated instruments and existing laboratory equipment. It is thus compatible with a wide range of analytic methods. Dosing of molecules can be done at any time via supernatant sampling and spheroids can easily be retrieved from the plate for further analysis. The Akura™ Twin plate is composed of a black-walled Polystyrene body bonded to a transparent continuous membrane. The black-walled wells help to eliminate fluorescent crosstalk between wells. In the Akura™ Twin Microplate, the membrane is made of COP and is 0.188 mm thick, allowing high-content imaging.
The Akura™ Twin platform allows the study of tissue-tissue interactions with the addition of immune competence to the 3D model via the circulation of immune cells in between the two spheroids.
The Starter Kit also contains Akura™ 96 Microplates for the formation of spheroids preceding their transfer and study in the Twin Microplate.
Your Question Answered
View AllDarwin Microfluidics being based in France, ships orders under Delivered At Place (DAP) incoterms. This means that for customers outside the European Union (EU), you are responsible for any applicable customs fees, duties, and taxes in addition to the shipping costs. These charges are determined by your local customs authority and must be paid by you upon the arrival of the shipment in your country.
We recommend contacting your local customs office for detailed information on these charges if you're ordering from outside the EU, as they can vary depending on the destination and the value of your order. Please note that these additional costs are not included in the shipping fees charged by Darwin Microfluidics.
If you've received your order from Darwin Microfluidics and found that a product is defective or missing, please follow these steps to resolve the issue:
Report immediately: Contact our customer service team as soon as possible. Reporting the issue promptly helps us address your concern more efficiently.
Provide details: When you contact us, please provide your order number, the name the order was placed under, and a detailed description of the issue. For defective products, include clear photos or a video that shows the defect.
Review: Our team will review your claim to determine the best course of action. We may ask for additional information or details about the problem.
Resolution: Depending on the situation, we may send a replacement for the defective or missing item, provide a refund, or offer another satisfactory resolution. Our goal is to ensure you are completely satisfied with your purchase.
Follow-up: We will keep you updated throughout the process and confirm when the issue has been resolved to your satisfaction.
We apologize for any inconvenience caused by a defective or missing item and are committed to resolving your issue as quickly and smoothly as possible.
At Darwin Microfluidics, our goal is to offer the most competitive prices directly as our list price, ensuring that all our customers receive great value without needing to navigate complex discount structures. Here’s a detailed look at our discount policy:
Competitive list prices: We work hard to ensure our list prices are among the most competitive in the market. This approach allows us to offer fair pricing to all our customers from the start, eliminating the need for frequent discounts.
Quantity-based discounts: For certain products, we offer quantity-based discounts directly on the product pages. These discounts are automatically applied based on the quantity of the product you purchase, providing savings for bulk purchases without the need for special codes or negotiations.
Bulk orders: While we strive to offer the best prices upfront, we understand that customers making large-scale purchases may have special considerations. In such cases, we invite you to discuss your needs with our sales team. Depending on the size and nature of your order, we may be able to offer tailored discounts or pricing adjustments.
We believe in transparency and simplicity in pricing, allowing you to make your purchases with confidence, knowing you're receiving a fair deal without the hassle of negotiating discounts. If you have any questions about pricing or discounts for bulk orders, please don't hesitate to reach out to our sales team for personalized assistance.
Please follow our returns & refund page.
Since Darwin Microfluidics sells exclusively to companies and institutions and is based in France, the VAT treatment for your orders depends on the location of your company or institution:
Within the EU (excluding France): For customers in other EU countries, the reverse charge mechanism applies. This means that VAT is not charged by us at the point of sale. Instead, it is your responsibility to account for the VAT at the standard rate applicable in your country under the reverse charge procedure. This process helps simplify cross-border transactions within the EU.
In France: For customers located in France, standard French VAT rates apply to all purchases. As a France-based company, we are required to charge VAT on sales to other French companies and institutions, which you can then reclaim according to local VAT procedures if applicable.
Outside the EU: For customers outside the European Union, sales are not subject to VAT by us. However, you may be subject to import duties, taxes, and charges that are not included in the item price or shipping cost. These charges are the buyer's responsibility and vary by country. We advise checking with your local customs office for more information.
Please ensure your VAT identification number is provided during the ordering process for EU transactions to qualify for the reverse charge mechanism. If you have any questions regarding VAT charges or need further assistance with VAT-related issues, please contact our customer service team.
We are unable to provide specific estimates for customs fees, duties, or taxes associated with your order. These charges are determined by the customs authority in your country and can vary based on a variety of factors, including the type of items purchased, their value, and the country to which they are being shipped.
We recommend contacting your local customs office directly to get the most accurate and up-to-date information regarding potential customs charges for your order. They can provide you with detailed guidelines on the fees you might expect to pay based on the products you're importing from us.
Please remember, these charges are the responsibility of the recipient and are not included in the shipping costs paid to Darwin Microfluidics.
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