This vessel-on-a-chip technology utilizes circular channels, to better mimic human physiological conditions, enabling the modeling of angiogenesis and biological barrier functions under flow. The design features one central channel where ECM can be loaded and two lateral channels.
General
This organ-on-a-chip device comprises one central channel and two adjacent lateral channels. Additionally, all channels are circular to better mimic vascular physiology as compared to rectangular channels.
The chip can model the interaction between the vascular network and any other tissue, the angiogenesis process, or even the endothelial barrier permeability. This is an ideal model to gain insight into vascular biology, study human physiology, and design new therapies.
The central channel can be loaded with a functional extracellular matrix (ECM) to allow the formation of a microvascular network while flowing medium and other cells in the lateral channels.
The system is made of PDMS and glass and is thus biocompatible, autoclavable, highly permeable to gas, and compatible with high-quality imaging.
Content
3x Microvascular and barrier chips
Specifications
| SKU |
B01_0028
|
| Channel type |
lateral |
central |
| Channel number |
2 |
1 |
| Inlet diameter (mm) |
3 |
2 |
| Inlet volume (µL) |
9 |
2 |
| Channel volume (µL) |
17.1 |
2.1 |
| Channel diameter (mm) |
1 |
0.5 |
| Channel length (mm) |
21.1 |
10 |
| Chip thickness (mm) |
6.5 |
| Example of function |
Flow |
ECM |
Chip material: PDMS, a biocompatible silicone, optically compatible, oxygen breathable and autoclavable at 121°C.
Documentation
? Microvascular and barrier chip - Application
