SynRAM 3D Inflammation Model

SynRAM model is a complete platform to study the inflammation pathway in a realistic environment. Enabling real-time tracking of rolling, adhesion and migration processes, it recreates a histological slice of co-cultured tissue and/or tumor cells with a lumen of endothelial cells.

Available in two kit sizes to start using the setup out of the box!

General

SynVivo's SynRAM model is designed to overcome the limitations of devices classically used in biology by taking into account fluid shear and size/topology observed in vivo.

The device allows to recreate the microenvironment and to easily model the transmigration phenomenon. By recapitulating a histological slice of co-cultured tissue and/or tumor cells with an endothelial cell lumen, the SynVivo platform provides a physiologically realistic model while allowing real-time monitoring of the rolling, adhesion, and migration processes.

• Mimic the physiological shear stress in a microvascular environment
• In vivo-like vascular morphology with fully enclosed lumen
• Cell-to-cell interaction is possible with co-culture
• Get real-time quantitative rolling, adhesion, and migration

This assay has been successfully validated against in vivo studies showing an excellent correlation with rolling speeds, adhesion patterns, and migration processes.

To run SynRAM assays, two kits formats are available:

To order the chips only, check our dedicated pages for microvascular and radial designs (ref SY-102008, SY-105001).

Examples of models developed using SynRAM

Real-time visualization of rolling, adhesion and migration

Real-time tracking of single-cell migration

Content

Specifications

IMN2 radial	SMN2 co-culture microvascular network
Outer channel (OC): 200 μm Tissue chamber: 1.8 mm diameter Depth: 100 μm Pillar spacing (SP): 8 µm Travel (T): 50 µm Pillar height: 100 µm	Idealized co-culture chip microvascular network with pillar barrier. Pillar height: 3 µm Pillar diameter: 10 µm Separation: 50 µm Depth: 100 µm

Documentation

?SynVivo brochure

?SynRAM idealized network technical manual

?SynRAM microvascular network technical manual

?SynRAM starter kit contents & description

?SynRAM assay kit contents & description

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