These idealized co-culture designs are helpful tools in the organ-on-chip field to mimic cellular interactions in vitro and model several biological systems in 3D. This design is composed of a central chamber allowing 3D tissue culture surrounded by two outer channels, for the modeling of a wide range of cell-cell interactions.
Description
The IMN3 Radial organ-on-chip design is made of a central 3D chamber filled with pillars (tissue chamber) and two outer channels. This side-by-side architecture enables the co-culture of different cell types with real-time visualization. These platforms allow the modeling of physiological shear stress and in vivo-like morphology of tissues.
The separation between the central and outer channels can be done with either slits or pillars and are available in several dimensions. In both cases, slits/pillars are spaced at regular intervals to create a barrier between the inner and outer chambers.
In the central chamber, pillars have a diameter of 25µm and are spaced by 50µm.
These designs can be used in a wide range of applications, for which specific product pages can be found in our bundle section.
Content
3x IMN3 Radial chips
Specifications
The chips have the format of a microscopic slide and are made of PDMS bonded to glass.
| |
SY-103002 |
SY-103003 |
SY-103004 |
SY-103006 |
SY-103007 |
| Outer channel (µm) |
200 |
200 |
200 |
100 |
100 |
| Barrier type |
Pillars
|
Pillars
|
Pillars |
Slits
|
Slits |
| Barrier gap (µm) |
3 |
8 |
8 |
50
|
50 |
| Slit width Ws (µm) |
- |
- |
- |
2 |
2 |
| Pillar height (µm) |
3 |
3 |
3 |
- |
- |
| Travel T (µm) |
100 |
50 |
100 |
100 |
20 |
| Depth (µm) |
100 |
100 |
100 |
100 |
100 |
For all chips, the chamber is filled with pillars of 25 µm diameter and separated by a distance of 50 µm.
